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Paroxysmal sympathetic hyperactivity (PSH) is a syndrome that causes episodes of increased activity of the sympathetic nervous system. Hyperactivity of the sympathetic nervous system can manifest as increased heart rate, increased respiration, increased blood pressure, diaphoresis , and hyperthermia . [ 1 ]
Serotonin, being a tryptamine (non-catecholamine) involved in higher brain functions, can cause dangerous hypertension and tachycardia from its effects on the sympathetic nervous system. [23] Symptoms caused by excessive adrenergic signalling can occur alongside those of serotonergic signalling.
Paroxysmal sympathetic hyperactivity; Pathophysiology of nerve entrapment; Pectoralis minor syndrome; Peripheral mononeuropathy; Peripheral neuropathy; Piriformis syndrome; Plexopathy; Polyneuropathy; Postural orthostatic tachycardia syndrome; Primary autonomic failure; Pronator teres syndrome; Proximal diabetic neuropathy; Pudendal nerve ...
Barbiturates such as pentobarbital have been shown to cause paradoxical hyperactivity in an estimated 1% of children, who display symptoms similar to the hyperactive-impulsive subtype of attention deficit hyperactivity disorder. Intravenous caffeine administration can return these patients' behavior to baseline levels. [11]
If sympathetic activity is elevated for an extended time, it can cause weight loss and other stress-related body changes. The list of conditions that can cause sympathetic hyperactivation includes severe brain injury, [56] spinal cord damage, [57] heart failure, [58] high blood pressure, [59] kidney disease, [60] and various types of stress.
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