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Dysautonomia, autonomic failure, or autonomic dysfunction is a condition in which the autonomic nervous system (ANS) does not work properly. This may affect the functioning of the heart , bladder , intestines , sweat glands , pupils , and blood vessels.
Postural orthostatic tachycardia syndrome (POTS) is a condition characterized by an abnormally large increase in heart rate upon sitting up or standing. [1] POTS is a disorder of the autonomic nervous system that can lead to a variety of symptoms, [10] including lightheadedness, brain fog, blurred vision, weakness, fatigue, headaches, heart palpitations, exercise intolerance, nausea ...
Per the Mayo Clinic, POTS "affects the autonomic nervous ... Sjogren's syndrome "is a disorder of your immune system identified by its two most common symptoms — dry eyes and a dry mouth ...
Orthostatic intolerance (OI) is the development of symptoms when standing upright that are relieved when reclining. [1] There are many types of orthostatic intolerance. OI can be a subcategory of dysautonomia, a disorder of the autonomic nervous system [2] occurring when an individual stands up. [3]
Pure autonomic failure (PAF) is an uncommon, sporadic neurodegenerative condition marked by a steadily declining autonomic regulation. [3] Bradbury and Eggleston originally described pure autonomic failure in 1925. [4] Patients usually present with orthostatic hypotension or syncope in midlife or later.
Signs and symptoms of Parkinson's disease are varied. Parkinson's disease affects movement, producing motor symptoms . [ 1 ] Non-motor symptoms, which include dysautonomia , cognitive and neurobehavioral problems, and sensory and sleep difficulties, are also common. [ 1 ]
Approximately 60% of patients require a wheelchair within five years of onset of the motor symptoms, and few patients survive beyond 12 years. [3] The disease progresses without remission at a variable rate. Those who present at an older age, those with parkinsonian features, and those with severe autonomic dysfunction have a poorer prognosis. [3]
The disorder may be associated with Addison's disease, atherosclerosis (build-up of fatty deposits in the arteries), diabetes, pheochromocytoma, porphyria, [17] long COVID, [18] [19] and certain neurological disorders, including autoimmune autonomic ganglionopathy, multiple system atrophy, and other forms of dysautonomia.