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The median effective dose is the dose that produces a quantal effect (all or nothing) in 50% of the population that takes it (median referring to the 50% population base). [6] It is also sometimes abbreviated as the ED 50, meaning "effective dose for 50% of the population". The ED50 is commonly used as a measure of the reasonable expectancy of ...
The ICRP defines an equivalent dose quantity for individual committed dose, which is used to measure the effect of inhaled or ingested radioactive materials. A committed dose from an internal source represents the same effective risk as the same amount of equivalent dose applied uniformly to the whole body from an external source.
The tissue weighting factors are used to convert an equivalent dose to a given tissue in the body, to an effective dose, a number that provides an estimation of total danger to the whole organism, as a result of the radiation dose to part of the body.
The deterministic effects that can lead to acute radiation syndrome only occur in the case of high doses (> ~10 rad or > 0.1 Gy) and high dose rates (> ~10 rad/h or > 0.1 Gy/h). A model of deterministic risk would require different weighting factors (not yet established) than are used in the calculation of equivalent and effective dose.
Effective dose is a dose quantity in the International Commission on Radiological Protection (ICRP) system of radiological protection. [1]It is the tissue-weighted sum of the equivalent doses in all specified tissues and organs of the human body and represents the stochastic health risk to the whole body, which is the probability of cancer induction and genetic effects, of low levels of ...
A committed dose from an internal source is intended to carry the same effective risk as the same amount of equivalent dose applied uniformly to the whole body from an external source, or the same amount of effective dose applied to part of the body.
In such cases, the effective dose is the amount and frequency that produces the desired effect, which can vary, and can be greater or less than the therapeutically effective dose. The Certain Safety Factor , also referred to as the Margin of Safety (MOS) , is the ratio of the lethal dose to 1% of population to the effective dose to 99% of the ...
The EC 50 of a quantal dose response curve represents the concentration of a compound where 50% of the population exhibit a response, [5] after a specified exposure duration. For clarification, a graded dose response curve shows the graded effect of the drug (y axis) over the dose of the drug (x axis) in one or an average of subjects.