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Schizophrenia is a serious mental illness that affects a person’s thoughts, feelings and behaviors. It often causes hallucinations, delusions , disordered speech and loss of touch with reality ...
Most schizophrenia medications, broadly known as antipsychotics, work by changing dopamine levels, a brain chemical that affects mood, motivation, and thinking, Kunovac explained.
While schizophrenia treatments primarily target the dopamine neurotransmitter system in the brain, Cobenfy goes after a different one, the cholinergic system, through muscarinic receptors ...
Schizophrenia affects around 0.3–0.7% of people at some point in their life. [19] [14] In areas of conflict this figure can rise to between 4.0 and 6.5%. [248] It occurs 1.4 times more frequently in males than females and typically appears earlier in men. [86] Worldwide, schizophrenia is the most common psychotic disorder. [55]
Schizophrenia is a neurodevelopmental disorder with no precise or single cause. Schizophrenia is thought to arise from multiple mechanisms and complex gene–environment interactions with vulnerability factors. [1][2] Risk factors of schizophrenia have been identified and include genetic factors, environmental factors such as experiences in ...
The dopamine hypothesis of schizophrenia or the dopamine hypothesis of psychosis is a model that attributes the positive symptoms of schizophrenia to a disturbed and hyperactive dopaminergic signal transduction. The model draws evidence from the observation that a large number of antipsychotics have dopamine- receptor antagonistic effects.