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A significant amount of research has been performed on glycosaminoglycans, especially glucosamine and chondroitin, for the treatment of arthritis.These compounds are commonly marketed as nutritional supplements and numerous 'soft therapeutic claims' are made about their health benefits - especially in aging populations. [1]
Glucosamine (C 6 H 13 NO 5) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Glucosamine is part of the structure of two polysaccharides, chitosan and chitin. Glucosamine is one of the most abundant monosaccharides. [2]
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Distinguished from chondroitin sulfate by the presence of iduronic acid, although some hexuronic acid monosaccharides may be glucuronic acid. [16] Keratan sulfate: Gal or Gal(6S) GlcNAc or GlcNAc(6S)-Gal(6S)β1-4GlcNAc(6S)β1-3: Keratan sulfate type II may be fucosylated. [21] Heparin: GlcUA or IdoUA(2S) GlcNAc or GlcNS or GlcNAc(6S) or GlcNS(6S)
Dermatan sulfate is a glycosaminoglycan (formerly called a mucopolysaccharide) found mostly in skin, but also in blood vessels, heart valves, tendons, and lungs.. It is also referred to as chondroitin sulfate B, [1] although it is no longer classified as a form of chondroitin sulfate by most sources.
The designation allows MSM to be added to processed foods. [15] The LD 50 of MSM is greater than 17.5 grams per kilogram of body weight. [16] Extensive research in animal models indicates MSM has a very low toxicity when administered both orally and topically. [17] [18] [19] MSM is considered 'Possibly Safe' at therapeutic doses. [13] [20]