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A megakaryocyte (from mega- 'large' karyo- 'cell nucleus' and -cyte 'cell') is a large bone marrow cell with a lobated nucleus that produces blood platelets ...
Langhans giant cells are named for the pathologist who discovered them, Theodor Langhans. Like many of the other kinds of giant cell formations, epithelioid macrophages fuse together and form a multinucleated giant cell. The nuclei form a circle or semicircle similar to the shape of a horseshoe away from the center of the cell.
During thrombopoiesis, the promegakaryocyte matures into the form of a megakaryocyte. From the megakaryocyte, platelets are formed. [1] The megakaryoblast is the beginning of the thrombocytic series or platelet forming series. Megakaryoblasts typically have a large oval-shaped nucleus or a nucleus that is lobed with many nuclei. [2]
In 2012, a research paper showed that when activated CD4+ T cells and monocytes are in close contact, interaction of CD40-CD40L between these two cells and subsequent IFNγ secretion by the T cells causes upregulation and secretion of fusion-related molecule DC-STAMP (dendritic cell-specific transmembrane protein) by the monocytes, which results in LGC formation.
CFU-GEMM is a colony forming unit that generates myeloid cells.CFU-GEMM cells are the oligopotential progenitor cells [1] [2] for myeloid cells; they are thus also called common myeloid progenitor cells or myeloid stem cells.
In order to eventually produce a megakaryocyte, the haematopoietic stem cell must generate myeloid cells, so it becomes a common myeloid progenitor, CFU-GEMM. This in turn develops into CFU-Meg, which is the colony forming unit that leads to the production of megakaryocytes. [1] [2] [3] Some sources prefer the term "CFU-Mega". [4]
A karyotype is the general appearance of the complete set of chromosomes in the cells of a species or in an individual organism, mainly including their sizes, numbers, and shapes. [ 1 ] [ 2 ] Karyotyping is the process by which a karyotype is discerned by determining the chromosome complement of an individual, including the number of ...
Megakaryocyte–erythroid progenitor cells must commit to becoming either platelet-producing megakaryocytes via megakaryopoiesis or erythrocyte-producing erythroblasts via erythropoiesis. [ 2 ] [ 3 ] Most of the blood cells produced in the bone marrow during hematopoiesis come from megakaryocyte–erythroid progenitor cells.