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During its maturation, the megakaryocyte grows in size and replicates its DNA without cytokinesis in a process called endomitosis. As a result, the nucleus of the megakaryocyte can become very large and lobulated, which, under a light microscope, can give the false impression that there are several nuclei.
During thrombopoiesis, the promegakaryocyte matures into the form of a megakaryocyte. From the megakaryocyte, platelets are formed. [1] The megakaryoblast is the beginning of the thrombocytic series or platelet forming series. Megakaryoblasts typically have a large oval-shaped nucleus or a nucleus that is lobed with many nuclei. [2]
Langhans giant cells are named for the pathologist who discovered them, Theodor Langhans. Like many of the other kinds of giant cell formations, epithelioid macrophages fuse together and form a multinucleated giant cell. The nuclei form a circle or semicircle similar to the shape of a horseshoe away from the center of the cell.
Megakaryocyte: Platelets if considered distinct cells, currently there's debate on the subject. Monocyte (white blood cell) Connective tissue macrophage (various types) Epidermal Langerhans cell: Osteoclast: in bone Dendritic cell: Microglial cell: central nervous system: Neutrophil granulocyte: myeloblast, promyelocyte, myelocyte, metamyelocyte
CFU-GEMM is a colony forming unit that generates myeloid cells.CFU-GEMM cells are the oligopotential progenitor cells [1] [2] for myeloid cells; they are thus also called common myeloid progenitor cells or myeloid stem cells.
Thrombopoietin (THPO) also known as megakaryocyte growth and development factor (MGDF) is a protein that in humans is encoded by the THPO gene. Thrombopoietin is a glycoprotein hormone produced by the liver and kidney which regulates the production of platelets .
In geometry and mathematical biology, a biconcave disc — also referred to as a discocyte [1] — is a geometric shape resembling an oblate spheroid with two concavities on the top and on the bottom. Biconcave discs appear in the study of cell biology, as an approximation to the shape of certain cells, including red blood cells.
A karyotype is the general appearance of the complete set of chromosomes in the cells of a species or in an individual organism, mainly including their sizes, numbers, and shapes. [ 1 ] [ 2 ] Karyotyping is the process by which a karyotype is discerned by determining the chromosome complement of an individual, including the number of ...