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The B-cell receptor (BCR) is a transmembrane protein on the surface of a B cell. A B-cell receptor includes both CD79 and the immunoglobulin. The plasma membrane of a B cell is indicated by the green phospholipids. The B- cell receptor extends both outside the cell (above the plasma membrane) and inside the cell (below the membrane). The B-cell ...
B cells, unlike the other two classes of lymphocytes, T cells and natural killer cells, express B cell receptors (BCRs) on their cell membrane. [1] BCRs allow the B cell to bind to a foreign antigen, against which it will initiate an antibody response. [1] B cell receptors are extremely specific, with all BCRs on a B cell recognizing the same ...
BAFF steady-state concentrations depend on B cells and also on the expression of BAFF-binding receptors. [8] BAFF is the natural ligand of three nonconventional tumor necrosis factor receptors named BAFF-R (BR3), TACI (transmembrane activator and calcium modulator and cyclophilin ligand interactor), and BCMA (B-cell maturation antigen), all of ...
CD79 (Cluster of Differentiation 79) is a transmembrane protein that forms a complex with the B-cell receptor (BCR) and generates a signal following recognition of antigen by the BCR. CD79 is composed of two distinct chains called CD79A and CD79B (also known as Igα and Igβ); these form a heterodimer on the surface of a B cell stabilized by ...
BLNK is essential for normal B-cell development as part of the B cell receptor signaling pathway. [supplied by OMIM] [10] [23] [24] Evidence also suggests that BLNK may have tumor suppressive activity through its interaction with Bruton's tyrosine kinase (Btk) [25] [26] and regulation of the pre-B cell checkpoint. [14] [27]
Because CD22 is restricted to B cells, it is an excellent target for immunotherapy of B cell malignancies. There are several mechanisms by which this can be achieved, namely monoclonal antibodies , bispecific antibodies , antibody-drug conjugates , radioimmunoconjugates or CAR-T cells .
The most common simplified overview description of the B cell differentiation pathway involves the following steps: an antigen interacts with the corresponding surface membrane immunoglobulin after which the B cell begins expressing receptors for growth factors secreted by T cells (BCGFs and IL-2), after these factors bind, the lymphocytes ...
57916 Ensembl ENSG00000240505 ENSMUSG00000010142 UniProt O14836 Q9ET35 RefSeq (mRNA) NM_012452 NM_021349 RefSeq (protein) NP_036584 NP_067324 Location (UCSC) Chr 17: 16.93 – 16.97 Mb Chr 11: 61.02 – 61.04 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Transmembrane activator and CAML interactor (TACI), also known as tumor necrosis factor receptor superfamily member 13B ...