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List of side effects of estradiol which may occur as a result of its use or have been associated with estrogen and/or progestogen therapy includes: [1] [2]. Gynecological: changes in vaginal bleeding, dysmenorrhea, increase in size of uterine leiomyomata, vaginitis including vaginal candidiasis, changes in cervical secretion and cervical ectropion, ovarian cancer, endometrial hyperplasia ...
As unopposed estrogen therapy (using estrogen alone without progesterone) increases the risk of endometrial hyperplasia and endometrial cancer in women with intact uteruses, estradiol is usually combined with a progestogen like progesterone or medroxyprogesterone acetate to prevent the effects of estradiol on the endometrium.
[8] [7] Estradiol cypionate is an estrogen ester and a long-lasting prodrug of estradiol in the body. [14] [8] [7] Because of this, it is considered to be a natural and bioidentical form of estrogen. [7] [18] [12] Estradiol cypionate was first described as well as introduced for medical use in 1952.
Side effects of estradiol valerate include breast tenderness, breast enlargement, nausea, headache, and fluid retention. [15] [13] [14] Estradiol valerate is an estrogen and hence is an agonist of the estrogen receptor, the biological target of estrogens like estradiol. [5] [4] [16] It is an estrogen ester and a prodrug of estradiol in the body.
Side effects of estradiol benzoate include breast tenderness, breast enlargement, nausea, headache, and fluid retention. [17] Estradiol benzoate is an estrogen and hence is an agonist of the estrogen receptor, the biological target of estrogens like estradiol. [4] [5] It is an estrogen ester and a prodrug of estradiol in the body.
Side effects of estradiol acetate include breast tenderness, breast enlargement, nausea, headache, and fluid retention. [7] [5] [6] Estradiol acetate is an estrogen and hence is an agonist of the estrogen receptor, the biological target of estrogens like estradiol. [8] [9] It is an estrogen ester and a prodrug of estradiol in the body.
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