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In the case of saccharides, when drawn in the Fischer projection the erythro isomer has two identical substituents on the same side and the threo isomer has them on opposite sides. [7] When drawn as a zig-zag chain, the erythro isomer has two identical substituents on different sides of the plane (anti).
The prefix "threo-" which derives from threose (and "erythro-" from a corresponding diastereomer erythrose) offer a useful way to describe general organic structures with adjacent chiral centers, where "the prefixes... designate the relative configuration of the centers". [3]
Erythrose is a tetrose saccharide with the chemical formula C 4 H 8 O 4.It has one aldehyde group, and is thus part of the aldose family. The natural isomer is D-erythrose; it is a diastereomer of D-threose.
Since the threo isomers are energetically favored, it is easy to epimerize out any of the undesired erythro isomers. The drug that contains only dextrorotatory methylphenidate is sometimes called d-TMP, although this name is only rarely used and it is much more commonly referred to as dexmethylphenidate, d-MPH, or d
I believe it is the other way round - threo = syn and erythro = anti. —Preceding unsigned comment added by 86.31.187.255 15:22, 12 December 2010 (UTC) I have checked the text against a textbook on this topic and statements made are correct (threo = anti) V8rik 17:48, 13 December 2010 (UTC)
3D molecular rendering of methylphenidate (MPH). This is a list of methylphenidate (MPH or MPD) analogues, or Phenidates.The most well known compound from this family, methylphenidate, is widely prescribed around the world for the treatment of attention deficit hyperactivity disorder (ADHD) and certain other indications.
Other names (2S)-2-Amino-3-hydroxysuccinic acid 3-Hydroxyaspartic acid ... D-threo-3-Hydroxyaspartate is a part of the siderophore ornibactin. [2] See also
3,4-dichloromethylphenidate (abbreviated as 3,4-DCMP, and incorrectly as 3,4-CTMP for the d,l-threo diastereomer) is a potent stimulant drug from the phenidate class closely related to methylphenidate. It acts as a potent serotonin-norepinephrine-dopamine reuptake inhibitor with a long duration of action. It has been sold online as a designer drug.