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The amount of vitamin A leaving the liver, bound to retinol binding protein (RBP), is under tight control as long as there are sufficient liver reserves. Only when liver content of vitamin A drops below approximately 20 μg/gram will concentration in the blood decline. [5] [72]
Plasma retinol-binding protein, the retinol transport vehicle in serum. [13] CRBP I/II, cellular-binding proteins involved in transport of retinol and metabolites into retinyl esters for storage or into retinoic acid. [14] CRABPs, cellular retinoic acid–binding proteins capable of binding retinol and retinoic acid with high affinity.
Vitamin A receptor, Stimulated by retinoic acid 6 or STRA6 protein was originally discovered as a transmembrane cell-surface receptor for retinol-binding protein. [1] [2] [3] STRA6 is unique as it functions both as a membrane transporter and a cell surface receptor, particularly as a cytokine receptor. In fact, STRA6 may be the first of a whole ...
Retinol-binding protein 4 has been a drug target for eye diseases as RBP4 is the sole carrier for retinol, which is an essential nutrient for the visual cycle. Animal studies using RBP4-antagonists showed that lowering RBP4 can lead to reduction in the accumulation of lipofuscin that leads to vision loss in eye diseases like Stargardt's disease ...
RBP1 is the carrier protein involved in the transport of retinol (vitamin A alcohol) from the liver storage site to peripheral tissue. Vitamin A is a fat-soluble vitamin necessary for growth, reproduction, differentiation of epithelial tissues, and vision. The gene harbors four exons encoding 24, 59, 33, and 16 amino acid residues, respectively.
19660 Ensembl ENSG00000114113 ENSMUSG00000032454 UniProt P50120 Q08652 RefSeq (mRNA) NM_004164 NM_009034 RefSeq (protein) NP_004155 NP_033060 Location (UCSC) Chr 3: 139.45 – 139.48 Mb Chr 9: 98.37 – 98.39 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Retinol-binding protein 2 (RBP2) is a protein that in humans is encoded by the RBP2 gene. Function RBP2 is an abundant protein ...
Any skin care expert will tell you that there’s no antiaging ingredient that does it all quite like retinol. The holy grail of skin care will tackle everything from preventing fine lines and ...
Retinol, also called vitamin A 1, is a fat-soluble vitamin in the vitamin A family that is found in food and used as a dietary supplement. [3] Retinol or other forms of vitamin A are needed for vision, cellular development, maintenance of skin and mucous membranes , immune function and reproductive development. [ 3 ]