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Rabies virus is estimated to cause around 55,000 deaths per year across the world [13] and has a death rate of nearly 100%. [14] These statistics coupled with the fact that there is currently no specific treatment, or antiviral drug [ 13 ] makes research on the virus of vital importance for the scientific community in order to possibly lower ...
The fourth step in the viral cycle is replication, which is defined by the rapid production of the viral genome. How a virus undergoes replication relies on the type of genetic material the virus possesses. Based on their genetic material, viruses will hijack the corresponding cellular machinery for said genetic material.
Transmission electron micrograph of Tobacco mosaic virus, the first virus to be discovered and a ribovirian. Diseases caused by viruses in Riboviria have been known for much of recorded history, though their cause was only discovered in modern times. Tobacco mosaic virus was discovered in 1898 and was the first virus to be discovered. [56]
After completing this process and infecting a dog with the resulting virus, Pasteur realized that the virus was less virulent. [7] Mostly, Pasteur worked with the rabies virus in rabbits. [8] Ultimately, to create his vaccine for rabies, Pasteur used a simple method that involved drying out tissue. As is described in his notebook:
Rabies is caused by a number of lyssaviruses including the rabies virus and Australian bat lyssavirus. [4] Duvenhage lyssavirus may cause a rabies-like infection. [33] The rabies virus is the type species of the Lyssavirus genus, in the family Rhabdoviridae, order Mononegavirales.
Replication cycle of vesicular stomatitis virus (VSV) Viral replication is cytoplasmic. The replication cycle is the same for most rhabdoviruses. All components required for early transcription and the nucleocapsid are released to the cytoplasm of the infected cell after the first steps of binding, penetration and uncoating take place. [9]
Viral shedding is the expulsion and release of virus progeny following successful reproduction during a host cell infection. Once replication has been completed and the host cell is exhausted of all resources in making viral progeny, the viruses may begin to leave the cell by several methods.
In addition, five more species have recently been discovered: West Caucasian bat virus, Aravan virus, Khujand virus, Irkut virus and Shimoni bat virus. [8] [9] The lyssavirus genus can be divided into four phylogroups based upon DNA sequence homology. Phylogroup I includes viruses, such as Rabies virus, Duvenhage virus, European bat lyssavirus ...