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The dorsal column–medial lemniscus pathway (DCML) (also known as the posterior column-medial lemniscus pathway (PCML) is the major sensory pathway of the central nervous system that conveys sensations of fine touch, vibration, two-point discrimination, and proprioception (body position) from the skin and joints.
Subacute combined degeneration of spinal cord, also known as myelosis funiculus, or funicular myelosis, [1] also Lichtheim's disease, [2] [3] and Putnam-Dana syndrome, [4] refers to degeneration of the posterior and lateral columns of the spinal cord as a result of vitamin B 12 deficiency (most common).
A small nerve may consist of a single funiculus, but a larger nerve will have several funiculi collected together into larger bundles known as fascicles. Fascicles are bound together in a common membrane, the epineurium. [1] [2] Funiculi in the spinal cord are columns of white matter. [3] [4] Examples include: Anterior funiculus of the spinal cord
The two main tracts are the dorsal spinocerebellar tract, and the ventral spinocerebellar tract. Both of these tracts are located in the peripheral region of the lateral funiculi (white matter columns). [1] Other tracts are the rostral spinocerebellar tract, and the cuneocerebellar tract (posterior external arcuate fibers). [2]
The dorsal column nuclei each have an associated nerve tract in the spinal cord, the gracile fasciculus and the cuneate fasciculus, together forming the dorsal columns. Both dorsal column nuclei contain synapses from afferent nerve fibers that have travelled in the spinal cord. [2] They then send on second-order neurons of the dorsal column ...
The lateral funiculus transmits the contralateral corticospinal and spinothalamic tracts. A lateral cutting of the spinal cord results in the transection of both ipsilateral posterior column and lateral funiculus and this produces Brown-Séquard syndrome. [1]
Dorsal column tracts (gracile fasciculus and cuneate fasciculus) (in blue). 3’. Gracile and cuneate nuclei. 4. Anterolateral corticospinal tract (in dotted line). 5. Pyramid. 6. Lemniscus. 7. Medial longitudinal fasciculus. 8. Ventral spinocerebellar fasciculus (in blue). 9. Dorsal spinocerebellar fasciculus (in yellow).
Collectively, the ascending sensory fibers are called the dorsal column because ascending fibers gather at the dorsal funiculus in the spinal cord. [5] The dorsal funiculus is located between the dorsal horn and the medial line in the spinal cord. There are three types of neurons in the pathway: first-, second-, and third-order neurons.