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[1] In some cases, a drug can cause the immune system to mistakenly think the body's own red blood cells are dangerous, foreign substances. Antibodies then develop against the red blood cells. The antibodies attach to red blood cells and cause them to break down too early. It is known that more than 150 drugs can cause this type of hemolytic ...
Of the drugs that cause DIL, hydralazine has been found to cause a higher incidence. Hydralazine is a medication used to treat high blood pressure. Approximately 5% of the patients who have taken hydralazine over long periods of time and in high doses have shown DIL-like symptoms. [8] Many of the other drugs have a low to very low risk to ...
The reagent is typically provided in two parts: [2] [1] [3] A mixture of 2% sodium nitroprusside and 2% acetaldehyde in water (solution A) [4] A solution of 2% sodium carbonate in water (solution B) [4] Separate storage of the aldehyde and base are necessary to prevent aldol polymerisation of the aldehyde.
Drugs which cause disulfiram-like reactions upon ingestion of alcohol as an unintended effect include: [6] [1] [7] Abacavir Cephalosporins , but only these with a methylthiotetrazole side chain or a methylthiodioxotriazine ring; thought to be due to common N -methylthiotetrazole metabolite , which is similar in structure to disulfiram. [ 8 ]
The charge of a molecule depends upon the pH of its solution. In an acidic medium, basic drugs are more charged and acidic drugs are less charged. The converse is true in a basic medium. For example, Naproxen is a non-steroidal anti-inflammatory drug that is a weak acid (its pKa value is 5.0). The gastric juice has a pH of 2.0. It is a three ...
In pharmacology, a drug is a chemical substance, typically of known structure, which, when administered to a living organism, produces a biological effect. [2] A pharmaceutical drug, also called a medication or medicine, is a chemical substance used to treat, cure, prevent, or diagnose a disease or to promote well-being. [3]
A number of drugs that cause QT prolongation does not directly block hERG, but reduces the trafficking of the mature protein to the surface of the cell. This includes probucol , which appears to enhance the intercellular degradation of hERG; and several cardiac glycosides , which reduces trafficking due to decreased intracellular potassium.
Anticonvulsant agents, such as phenytoin, are associated with common forms of gingival overgrowth. [2] It is caused by the increase of metabolites from the breakdown of anticonvulsants in the body. [3] It should also be noted that concurrent usage of different anticonvulsants in children has resulted in accumulative gingival enlargement. [2]