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The first step in initiation is formation of the pre-initiation complex, 48S PIC. The small ribosomal subunit and various eukaryotic initiation factors are recruited to the mRNA 5′ TL and to form the 48S PIC complex, which scans 5′ to 3′ along the mRNA transcript, inspecting each successive triplet for a functional start codon.
Translation initiation is the process by which the ribosome and its associated factors bind to an mRNA and are assembled at the start codon. This process is defined as either cap-dependent, in which the ribosome binds initially at the 5' cap and then travels to the stop codon, or as cap-independent, where the ribosome does not initially bind ...
Leaky scanning is a mechanism used during the initiation phase of eukaryotic translation that enables regulation of gene expression.During initiation, the small 40S ribosomal subunit (as a 43S PIC) "scans" or moves in a 5' --> 3' direction along the 5'UTR to locate a start codon to commence elongation.
Ukuthwasa is a traditional African practice that involves a spiritual calling and initiation process for individuals chosen by their ancestors to become healers or diviners. The Xhosa term " ukuthwasa " translates to "come out" or "be reborn," symbolising the transformative nature of the experience.
Translation initiation is sometimes described as three step process which initiation factors help to carry out. First, the tRNA carrying a methionine amino acid binds to the small subunit of ribosome, then binds to the mRNA, and finally joins together with the large subunit of ribosome. The initiation factors that help with this process each ...
In rare exceptions, such as translation by viral IRES-containing mRNAs, 'cap-binding' and/or 'scanning' are not required for initiation, although AUG is still typically used as the first codon. RAN translation is an exception to the canonical rules as it uses variable start site selection and initiates from a non-AUG codon, but may still depend ...
Jungian archetypes are a concept from psychology that refers to a universal, inherited idea, pattern of thought, or image that is present in the collective unconscious of all human beings. The psychic counterpart of instinct , archetypes are thought to be the basis of many of the common themes and symbols that appear in stories, myths, and ...
After being chosen, shamans go through an initiation rite. These rites are meant to gain or transfer the patronage of a spirit. Among Visayans, this ritual is known as the tupad or tupadan. In cases of people with "shamanic illness", these initiation rites are regarded as the cure, where the initiate regains health or sanity by conceding to the ...