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Chronic histoplasmosis cases can resemble tuberculosis; [9] [10] disseminated histoplasmosis affects multiple organ systems and is fatal unless treated. [11] While histoplasmosis is the most common cause of mediastinitis, this remains a relatively rare disease. Severe infections can cause hepatosplenomegaly, lymphadenopathy, and adrenal ...
Lung cancer is the most diagnosed and deadliest cancer worldwide, with 2.2 million cases in 2020 resulting in 1.8 million deaths. [3] Lung cancer is rare in those younger than 40; the average age at diagnosis is 70 years, and the average age at death 72. [2] Incidence and outcomes vary widely across the world, depending on patterns of tobacco use.
There are many possible causes of mediastinal lymphadenopathy, including: Tuberculosis; Sarcoidosis; Lung cancer/oesophageal cancer; Lymphangitis carcinomatosa; Cystic fibrosis; Histoplasmosis; Acute lymphoblastic leukemia; Coccidioidomycosis; Lymphoma [1] Whipple's disease [2] Goodpasture syndrome; Hypersensitivity pneumonitis
Cryptococcus neoformans is a fungus that causes cryptococcosis, which can lead to pulmonary infection as well as nervous system infections, like meningitis. [25] [26] Histoplasma capsulatum is a species of fungus known to cause histoplasmosis, which can present with an array of symptoms, but often involves respiratory infection. [27] [28]
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Both chemotherapy (drugs to treat cancer) and radiofrequency ablation (destroying cancer with radio waves) can cause lung cancers to develop cavities, which is a sign of a good response to treatment. [2] It is possible to have both an infection and lung cancer in the same cavity; the most common combination is primary lung cancer and ...