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While histoplasmosis is the most common cause of mediastinitis, this remains a relatively rare disease. Severe infections can cause hepatosplenomegaly, lymphadenopathy, and adrenal enlargement. [4] Lesions often left calcification nodules as they are healed. [12]
One study in the US showed about a 0.09 to 0.29 per million increase in mortality rates although the cause specific cause was unclear. [8] Most of the outcomes collected are from patients diagnosed with farmer's or bird breeder's lung and thus the degree to which this data can be extrapolated to other types of HP is uncertain.
A lung nodule or pulmonary nodule is a relatively small focal density in the lung. A solitary pulmonary nodule (SPN) or coin lesion, [1] is a mass in the lung smaller than three centimeters in diameter. A pulmonary micronodule has a diameter of less than three millimetres. [2] There may also be multiple nodules.
Primary pulmonary histoplasmosis is caused by inhalation of Histoplasma capsulatum spores, and approximately 10% of people with this acute infection develop erythema nodosum. [ 1 ] : 316 See also
The cannonball sign is a radiological term used to describe the presence of multiple, well-circumscribed, round opacities seen on X-ray or CT imaging, typically in the lungs. [1] This finding is most commonly associated with hematogenous metastases, where malignant cells spread to the lungs via the bloodstream, forming discrete nodules that ...
Histoplasma capsulatum is a species of dimorphic fungus.Its sexual form is called Ajellomyces capsulatus.It can cause pulmonary and disseminated histoplasmosis.. Histoplasma capsulatum is "distributed worldwide, except in Antarctica, but most often associated with river valleys" [1] and occurs chiefly in the "Central and Eastern United States" [2] followed by "Central and South America, and ...
Caseous necrosis in the kidney. In caseous necrosis no histological architecture is preserved (unlike with coagulative necrosis). [5] [6] On microscopic examination with H&E staining, the area is acellular, characterised by amorphous, roughly granular eosinophilic debris of now dead cells, [6] also containing interspearsed haematoxyphilic remnants of cell nucleus contents. [5]
[1] [7] It usually causes cough, difficulty breathing and fever, and can lead to respiratory failure. [4] Involvement outside the lungs is rare but, can occur as a disseminated type affecting lymph nodes, spleen, liver, bone marrow, eyes, kidneys, thyroid, gastrointestinal tract or other organs.