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Autoimmune encephalitis (AIE) is a type of encephalitis, and one of the most common causes of noninfectious encephalitis. It can be triggered by tumors , infections , or it may be cryptogenic . The neurological manifestations can be either acute or subacute and usually develop within six weeks.
Anti-VGKC-complex encephalitis are caused by antibodies against the voltage gated potassium channel-complex (VGKC-complex) and are implicated in several autoimmune conditions including limbic encephalitis, epilepsy and neuromyotonia (i.e. Isaacs' Syndrome). [1] Research into autoimmune encephalitides have significantly advanced recently. Both ...
Encephalitis with meningitis is known as meningoencephalitis, while encephalitis with involvement of the spinal cord is known as encephalomyelitis. [ 2 ] The word is from Ancient Greek ἐγκέφαλος , enképhalos 'brain', [ 37 ] composed of ἐν , en , 'in' and κεφαλή , kephalé , 'head', and the medical suffix -itis 'inflammation'.
Anti-N-methyl-D-aspartate (anti-NMDA) receptor antibodies, which are also associated with seizures and a movement disorder, and related to anti-NMDA receptor encephalitis. NAIM or "Nonvasculitic autoimmune inflammatory meningoencephalitis" (NAIM). [16] They can be divided into GFAP- and GFAP+ cases.
Successful treatment in these cases was credited to "awareness of Balamuthia as the causative agent of encephalitis and early initiation of antimicrobial therapy." [19] In one case, cloxacillin, ceftriaxone, and amphotericin B were tried, but this treatment protocol did not prove effective. [20]
While ADEM and MS both involve autoimmune demyelination, they differ in many clinical, genetic, imaging, and histopathological aspects. [ 14 ] [ 47 ] Some authors consider MS and its borderline forms to constitute a spectrum, differing only in chronicity, severity, and clinical course, [ 48 ] [ 49 ] while others consider them discretely ...
Limbic encephalitis is associated with an autoimmune reaction. [1] In non-paraneoplastic limbic encephalitis, this is typically due to infection (commonly herpes simplex virus) or as a systemic autoimmune disorder. [13] Limbic encephalitis associated with cancer or tumors is called paraneoplastic limbic encephalitis. [citation needed]
Treatment has often also used combination therapy with multiple other antimicrobials in addition to amphotericin, such as fluconazole, miconazole, rifampicin and azithromycin. They have shown limited success only when administered early in the course of an infection.