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Cholestasis is a condition where the flow of bile from the liver to the duodenum is impaired. [1] The two basic distinctions are: [1] obstructive type of cholestasis, where there is a mechanical blockage in the duct system that can occur from a gallstone or malignancy, and
Neonatal cholestasis refers to elevated levels of conjugated bilirubin identified in newborn infants within the first few months of life. [1] Conjugated hyperbilirubinemia is clinically defined as >20% of total serum bilirubin or conjugated bilirubin concentration greater than 1.0 mg/dL regardless of total serum bilirubin concentration. [ 2 ]
Primary biliary cholangitis (PBC), previously known as primary biliary cirrhosis, is an autoimmune disease of the liver. [1] [2] [3] It results from a slow, progressive destruction of the small bile ducts of the liver, causing bile and other toxins to build up in the liver, a condition called cholestasis.
Bile (yellow material) in a liver biopsy stained with hematoxylin-eosin in a condition called cholestasis (setting of bile stasi). Bile (from Latin bilis), or gall, is a yellow-green/misty green fluid produced by the liver of most vertebrates that aids the digestion of lipids in the small intestine.
[2] [3] However, when a gallstone obstructs the bile duct and causes acute cholestasis, a reflexive smooth muscle spasm often occurs, resulting in an intense cramp-like visceral pain in the right upper part of the abdomen known as a biliary colic (or "gallbladder attack"). [4] This happens in 1–4% of those with gallstones each year. [4]
Indonesia, [c] officially the Republic of Indonesia, [d] is a country in Southeast Asia and Oceania, between the Indian and Pacific oceans. Comprising over 17,000 islands, including Sumatra, Java, Sulawesi, and parts of Borneo and New Guinea, Indonesia is the world's largest archipelagic state and the 14th-largest country by area, at 1,904,569 square kilometres (735,358 square miles).
Djohar Arifin Husin, PSSI's chairman at the time, chose a new league operator, PT Liga Prima Indonesia Sportindo (LPIS), instead of LI. [3] [4] LPIS then proceeded to organise a new league, Indonesia Premier League or Liga Primer Indonesia for one full season and two seasons which went unfinished (2011 and 2013).
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