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It has been thought that if someone is deficient in vitamin B 12 and folic acid, the vitamin B 12 deficiency must be treated first. However, the basis for this has been challenged, although due to ethical considerations it is no longer able to be tested if "neuropathy is made more severe as a result of giving folic acid to vitamin B 12 ...
Vitamin B 6, pyridoxine, has been associated with peripheral nerve damage both in cases of deficiency and excess. [32] Deficiency of vitamin B 12 causes subacute combined degeneration , a disease classically associated with a central demyelinating process; however, it also presents with a painful peripheral neuropathy.
Nutritional optic neuropathy is treated with improved nutrition. A well-balanced diet with plenty of protein and green leafy vegetables, vitamin supplementation (thiamine, vitamin B 12, folic acid, multivitamins), and reduction of smoking and/or drinking are the mainstay of treatment. Again, prognosis is variable and dependent upon the affected ...
The relationship between the amount of vitamin B 6 consumed and the serum levels of those who consume it varies between individuals. [52] Some people may have high serum concentrations without neuropathy symptoms. [13] [53] [54] It is not known if inhalation of vitamin B 6 while, for example, working with animal feed containing vitamin B 6 is ...
Peripheral neuropathy may be classified according to the number and distribution of nerves affected (mononeuropathy, mononeuritis multiplex, or polyneuropathy), the type of nerve fiber predominantly affected (motor, sensory, autonomic), or the process affecting the nerves; e.g., inflammation (), compression (compression neuropathy), chemotherapy (chemotherapy-induced peripheral neuropathy).
Vitamin B6 is thought to lead to neuropathy due to its cytoskeletal and microtubule toxicity leading to nerve cell loss with prolonged overdosing. [ 2 ] Possible infectious causes of sensory neuronopathy include HIV (in which lymphocyte infiltrates have been observed in the dorsal root ganglion), Human T-lymphotropic virus 1 , Epstein-Barr ...