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2. Clark's rule - Wikipedia

   en.wikipedia.org/wiki/Clark's_rule

   Clark's rule is a medical term referring to a mathematical formula used to calculate the proper dosage of medicine for children aged 2–17 based on the weight of the patient and the appropriate adult dose. [1] The formula was named after Cecil Belfield Clarke (1894–1970), a Barbadian physician who practiced throughout the UK, the West Indies ...

3. Atomoxetine - Wikipedia

   en.wikipedia.org/wiki/Atomoxetine

   Atomoxetine is excreted unchanged in urine at <3% in both extensive and poor CYP2D6 metabolizers, with >96% and 80% of a total dose being excreted in urine, respectively. [10] The fractions excreted in urine as 4-hydroxyatomoxetine and its glucuronide account for 86% of a given dose in extensive metabolizers, but only 40% in poor metabolizers. [10]

4. Selective norepinephrine reuptake inhibitor - Wikipedia

   en.wikipedia.org/wiki/Selective_norepinephrine...

   The dose should be increased after a minimum of 3 days up to approximately 1.2 mg/kg daily (target dose) as a single or two divided doses (in the morning and late afternoon). For children older than 6 years old, over 70 kg, acute treatment should be started with 40 mg/day orally and increased up to 80 mg/day after a minimum of 3 days.

5. Model-Informed Precision Dosing - Wikipedia

   en.wikipedia.org/.../Model-informed_Precision_Dosing

   Model-Informed Precision Dosing (MIPD for short) is the use of pharmacometric models with computer software to optimize drug dosage for an individual patient. [1]Developed in the late 1960s under the impetus of clinical pharmacologists such as Lewis Sheiner and Roger Jelliffe, these approaches involve applying the equations and parameters describing a drug's pharmacokinetics and ...

6. US FDA flags dosing risks from compounded versions of ... - AOL

   www.aol.com/news/us-fda-flags-dosing-risks...

   (Reuters) -The U.S. Food and Drug Administration on Friday warned patients and doctors about dosing errors associated with compounded versions of Novo Nordisk's weight-loss and diabetes drugs.

7. Norepinephrine reuptake inhibitor - Wikipedia

   en.wikipedia.org/wiki/Norepinephrine_reuptake...

   Norepinephrine Epinephrine. A norepinephrine reuptake inhibitor (NRI, NERI) or noradrenaline reuptake inhibitor or adrenergic reuptake inhibitor (ARI), is a type of drug that acts as a reuptake inhibitor for the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline) by blocking the action of the norepinephrine transporter (NET).