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They worked primarily by suppressing appetite, and had other beneficial effects such as increased alertness. Use of amphetamines increased over the subsequent decades, including Obetrol and culminating in the "rainbow diet pill" regime. [38] This was a combination of multiple pills, all thought to help with weight loss, taken throughout the day.
Between 16.4% and 24.8% achieved at least a 10% decrease in body fat. [4] After orlistat was stopped, a significant number of subjects regained weight—up to 35% of the weight they had lost. [ 4 ] It reduces the incidence of diabetes type II in people who are obese around the same amount that lifestyle changes do. [ 12 ]
[10] [18] When used in routine care, there is evidence that VLCDs achieve average weight loss at 1 year around 10 kilograms (22 lb) [19] or about 4% more weight loss over the short term. [20] VLCDs can achieve higher short-term weight loss compared to other more modest or gradual calorie restricted diets , and the maintained long-term weight ...