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Some core symptoms of depression, such as rumination, low self-esteem, guilt, and depressed mood cannot be assessed in animals as they require subjective reporting. [130] From an evolutionary standpoint, the behavior correlates of defeats of loss are thought to be an adaptive response to prevent further loss.
Depression is commonly attributed to a deficiency in monoamines, such as serotonin. The monoamine hypothesis of depression suggests that depression is primarily caused by a deficiency of several monoamines, namely serotonin, dopamine and norepinephrine. [2] This hypothesis is widely accepted due to its simplicity. [3]
Legal cannabis (marijuana) product. Overconsumption and reliance could lead to cannabis-induced amotivational syndrome. The term amotivational syndrome was first devised to understand and explain the diminished drive and desire to work or compete among the population of youth who are frequent consumers of cannabis and has since been researched through various methodological studies with this ...
[96] [97] Low self-esteem in particular can result in aggression, self-deprecating behavior, anxiety, and other mental disorders. [98] Being perceived as someone who does not "fit in" can result in bullying and other types of emotional abuse, [99] [100] which can lead to the victim experiencing depression, anger, and loneliness. [101]
The dopamine D 1 receptor appears to have an important role in motivation and reward. [38] Centrally acting dopamine D 1-like receptor agonists like tavapadon and razpipadon and D 1 receptor positive modulators like mevidalen and glovadalen are under development for medical use, including treatment of Parkinson's disease and notably of dementia ...
Symptoms of ADHD that particularly relate to disinhibition and irritability in addition to low-mood and self-esteem as a result of symptom expression might be confusable with dysthymia and bipolar disorder as well as with borderline personality disorder, however they are comorbid at a significantly increased rate relative to the general population.