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PEGylation (or pegylation) is the process of both covalent and non-covalent attachment or amalgamation of polyethylene glycol (PEG, in pharmacy called macrogol) polymer chains to molecules and macrostructures, such as a drug, therapeutic protein or vesicle, which is then described as PEGylated.
PEGylation offers a number of benefits for pharmaceutical applications such as improved water solubility, high mobility in solution, as well as low toxicity and low immunogenicity. This does however depend on the molecular weight of the attached PEG.
PEGylation of adenoviruses for gene therapy can help prevent adverse reactions due to pre-existing adenovirus immunity. [8] A PEGylated lipid is used as an excipient in both the Moderna and Pfizer–BioNTech vaccines for SARS-CoV-2. Both RNA vaccines consist of messenger RNA, or mRNA, encased in a bubble of oily molecules called lipids ...
New research on the potential health benefits of fizzy water has revealed some surprising positives - but also some negatives. The study suggests sparkling water could help people lose weight by ...
"Hearst Magazines and Yahoo may earn commission or revenue on some items through these links." Acute inflammation, like the redness and swelling that occurs with an injury, is a sign that your ...
Ethoxylation is commonly practiced, albeit on a much smaller scale, in the biotechnology and pharmaceutical industries to increase water solubility and, in the case of pharmaceuticals, circulatory half-life of non-polar organic compounds.
For an added health boost, Shapiro recommends starting your day with a glass of lemon or ginger water. Citrus fruits, like lemons, are high in vitamin C—a vitamin with antioxidant and anti ...
Glycopegylation "is a site-selective PEGylation method developed for modifying complex glycoproteins". [1] It can be useful to improve bioavailability and extend the half-life of various therapeutic proteins. [2] [1] [3] Examples of glycopegylated molecules include pegozafermin [4] and recombinant factor IX. [5]