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The open field is an arena with walls to prevent escape. Commonly, the field is marked with a grid and square crossings. The center of the field is marked with a different color to differentiate from the other squares. In the modern open field apparatus, infrared beams or video cameras with associated software can be used to automate the ...
The test rather reflects the anxiolytic effects of antidepressants and the response is seen only after chronic treatment with antidepressants. Elevated plus maze. Open field: [38] Rodents tend to avoid brightly illuminated areas, and this avoidance is interpreted as a symptom of anxiety. Open field is a bright enclosure and during the test ...
The LDB apparatus has two compartments. The light compartment is 2/3 of the box and is brightly lit and open. The dark compartment is 1/3 of the total box and is covered and dark. A door of 7 cm connects the two compartments. [2] Rodents prefer darker areas over lighter areas.
The test uses an elevated, plus-shaped (+) apparatus with two open and two enclosed arms. The behavioral model is based on the general aversion of rodents to open spaces. This aversion leads to thigmotaxis : a preference for remaining in enclosed spaces or close to the edges of a bounded space.
The test was first developed by Dr. Carol Barnes in 1979. [1] The test subjects are usually rodents such as mice or lab rats , which either serve as a control or may have some genetic variable or deficiency present in them which will cause them to react to the maze differently.
The main strength of the tail suspension test is its predictive validity– performance on the test can be altered by drugs that improve depressive symptoms in people. Specifically, if antidepressant agents are administered before the test, the animal will struggle for a longer period of time than if not and exhibit more escape behaviors. [1]
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Rodents have been employed in biomedical experimentation from the 1650s. [1] Rodent studies up to the early 19th century were mainly physiological or toxicological.The first rodent behavioral study was carried out in 1822, a purely observational study [2], while quantitative rodent behavioral testing began in the late 19th century [1] [2].
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