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Polyclonal antibodies (pAbs) are antibodies that are secreted by different B cell lineages within the body (whereas monoclonal antibodies come from a single cell lineage). They are a collection of immunoglobulin molecules that react against a specific antigen , each identifying a different epitope .
This list of over 500 monoclonal antibodies includes approved and investigational drugs as well as drugs that have been withdrawn from market; consequently, the column Use does not necessarily indicate clinical usage. See the list of FDA-approved therapeutic monoclonal antibodies in the monoclonal antibody therapy page.
Hence the term "polyclonal", which derives from the words poly, meaning many, and clones from Greek klōn, meaning sprout or twig; [3] [4] [5] a clone is a group of cells arising from a common "mother" cell. The antibodies thus produced in a polyclonal response are known as polyclonal antibodies.
Pages in category "Polyclonal antibodies" The following 10 pages are in this category, out of 10 total. This list may not reflect recent changes. ...
Humanized monoclonal antibodies are identified with the suffix "-zumab". They mostly originate from a human but differ in the component that attaches to its target. [9] An example of a humanized monoclonal antibody is crizanlizumab, which treats sickle cell disease. [8] Human monoclonal antibodies are identified with the suffix "-umab".
Clonality implies the state of a cell or a substance being derived from one source or the other. Thus there are terms like polyclonal—derived from many clones; oligoclonal [2] —derived from a few clones; and monoclonal—derived from one clone. These terms are most commonly used in context of antibodies or immunocytes.
Clonal antibodies can either be monoclonal or polyclonal. Monoclonal antibodies are clones of one antibody; therefore, monoclonal antibodies can only bind to one target. Polyclonal antibodies are clones of multiple antibodies and immune cells, so they can bind to various targets. [4] Recombinant clonal antibodies are produced through in-vitro ...
For example, a labeled secondary antibody raised against rabbit IgG, is useful with any primary antibody raised in rabbit. This is particularly useful when a researcher is labeling more than one primary antibody, whether due to polyclonal selection producing an array of primary antibodies for a singular antigen or when there is interest in ...