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A phase 1 clinical trial in 2004 demonstrated the safety and tolerability of mapatumumab in cancer patients with advanced solid tumors or non-Hodgkin’s lymphoma, and supported further evaluation in phase 2 clinical trials, both as a single agent and in combination with chemotherapy. [4]
Phase II clinical programs historically have experienced the lowest success rate of the four development phases. In 2010, the percentage of Phase II trials that proceeded to Phase III was 18%, [16] and only 31% of developmental candidates advanced from Phase II to Phase III in a study of trials over 2006–2015. [17]
A Phase 2 clinical trial entitled First-Line Gemcitabine, Cisplatin + Ipilimumab for Metastatic Urothelial Carcinoma was first reported in 2015 [66] Thirty-six patients were treated with chemotherapy, adding ipilimumab after the second 21-day cycle. Though the study did not meet its primary endpoint, a significant expansion of circulating CD4 ...
Groundbreaking cancer trials are producing “incredibly impressive” results, with seriously ill people going into remission for months and years, according to a leading hospital.
This new technology was also found to work on colon cancer and the company had plans to push forward with phase 2 trials for late-stage colon cancer. The major advantage CancerVax enjoyed was that drug discovery was conducted at a research institute with the founder of CancerVax holding all commercialization rights to the technology that were ...
A 2013 study analyzing 8907 interventional trials registered in ClinicalTrials.gov found that 23.2% of trials had abstract-linked result articles and 7.3% of trials had registry-linked articles. 2.7% of trials had both types of links. Most trials are linked to a single result article (76.4%). [24]
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