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The purpose of a dialyzer is to separate the analyte from interfering substances such as protein, whose large molecules do not go through the dialysis membrane but go to a separate waste stream. The reagents, sample and reagent volumes, flow rates, and other aspects of the instrument analysis depend on which analyte is being measured.
Kolff's first prototype dialyzer was developed in 1943, built from orange juice cans, used auto parts, and sausage casings. [3] Over a two-year span, Kolff had attempted to treat 15 people with his machine, but all had died. In 1945, Kolff successfully treated his first patient, a 67-year-old woman, from kidney failure using his hemodialysis ...
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Haas was able to develop a dialyzer consisting of U-shaped collodion tubes immersed in a dialysate bath placed in a glass cylinder. He performed several hemodialysis procedures in uremics between 1924 and 1928, and reported for the first time the clinical results obtained. In 1928, Haas introduced heparin into the dialysis procedure. Because of ...
The growth of dialysis facilities in the United States is the result of more Americans developing end-stage renal disease. From 2001 to 2011 the number increased by about 49.7% from 411,000 citizens to 615,000 citizens. In 2001 there were only 296,000 Americans on some form of dialysis.
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Hemofiltration is sometimes used in combination with hemodialysis, when it is termed hemodiafiltration. Blood is pumped through the blood compartment of a high flux dialyzer, and a high rate of ultrafiltration is used, so there is a high rate of movement of water and solutes from blood to dialysate that must be replaced by substitution fluid that is infused directly into the blood line.
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