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Vaughan Williams was a pharmacology tutor at Hertford College, Oxford. One of his students, Bramah N. Singh, [3] contributed to the development of the classification system. The system is therefore sometimes known as the Singh-Vaughan Williams classification. The five main classes in the Vaughan Williams classification of antiarrhythmic agents are:
Representation of the ion channel opening/closing that antiarrhythmics act upon . Antiarrhythmics are broad class of drugs that are used treat heart rhythm irregularities. [16] Utilizing the Vaughan-Williams (VW) system, antiarrhymic drugs are classified into four main classes based on their mechanism of action. Class I antiarrhymics lead to ...
(Edward) Miles Vaughan Williams (8 August 1918 – 31 August 2016) was a British cardiac pharmacologist and academic. He is best known for the Vaughan Williams classification of antidysrhythmic drugs. [1] From 1955 to 1985, he was a Fellow of Hertford College, Oxford, and its Tutor in medicine. [2]
Procainamide (PCA) is a medication of the antiarrhythmic class used for the treatment of cardiac arrhythmias. It is a sodium channel blocker of cardiomyocytes; thus it is classified by the Vaughan Williams classification system as class Ia. In addition to blocking the I Na current, it inhibits the I Kr rectifier K+ current. [1]
They are classified as "Type I" in the Vaughan Williams classification. Class I antiarrhythmic agents interfere with the (Na +) channel. Class I agents are grouped by their effect on the Na + channel, and by their effect on cardiac action potentials. Class I agents are called Membrane Stabilizing Agents.
Dronedarone displays amiodarone-like class III antiarrhythmic activity in vitro [12] and in clinical trials. [6] The drug also appears to exhibit activity in each of the 4 Vaughan-Williams antiarrhythmic classes.
The result of their cooperation formed the basis of 'Vaughan Williams Classification' of antiarrhythmic drugs. Returning home he developed new models for the assessment of antiarrhythmic action, which were soon widely applied. He also studied the electrophysiologic changes due to drugs, ischemia or heart failure.
Proarrhythmia is a new or more frequent occurrence of pre-existing arrhythmias, paradoxically precipitated by antiarrhythmic therapy, which means it is a side effect associated with the administration of some existing antiarrhythmic drugs, as well as drugs for other indications. In other words, it is a tendency of antiarrhythmic drugs to ...