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GLP-1 drugs used for weight loss involve all kinds of side effects—good and not-so-good—that may or may not strike the average user. (Reminder that there are many of these meds now.
“Although data is sparse, since people lose so much more weight with GLP-1 medications compared with diet and exercise alone, the amount of muscle loss is more for [those on these] medications.”
It could be that "people get on GLP-1s to lose weight, and as a consequence of the weight loss, feel better.” But it’s also possible that GLP-1s are benefiting the body in other ways, he says.
They worked primarily by suppressing appetite, and had other beneficial effects such as increased alertness. Use of amphetamines increased over the subsequent decades, including Obetrol and culminating in the "rainbow diet pill" regime. [38] This was a combination of multiple pills, all thought to help with weight loss, taken throughout the day.
Serious side effects may include abuse, but do not include pulmonary hypertension or valvular heart disease, as the latter complications were caused by the fenfluramine component of the "fen-phen" combination. [3] Phentermine is an norepinephrine and dopamine releasing agent (NDRA) and produces stimulant, rewarding, and appetite suppressant ...
The effects of the ECA stack on weight loss are primarily due to the ephedrine component. Ephedrine acts both as an α and β adrenergic agonist , stimulating the release of norepinephrine . [ 8 ] Increased circulating norepinephrine in the body then acts on brown adipose tissue and skeletal muscle [ 9 ] by increasing cyclic adenosine ...
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