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The gastrointestinal tract (GI tract, digestive tract, alimentary canal) is the tract or passageway of the digestive system that leads from the mouth to the anus. The GI tract contains all the major organs of the digestive system, in humans and other animals, including the esophagus , stomach , and intestines .
Gastrointestinal physiology is the branch of human physiology that addresses the physical function of the gastrointestinal (GI) tract.The function of the GI tract is to process ingested food by mechanical and chemical means, extract nutrients and excrete waste products.
Most of the digestion of food takes place in the small intestine which is the longest part of the GI tract. The largest part of the GI tract is the colon or large intestine. Water is absorbed here and the remaining waste matter is stored prior to defecation. [2] There are many specialised cells of the GI tract.
The digestive system functions to move material through the GI tract via peristalsis, break down that material via digestion, absorb nutrients for use throughout the body, and remove waste from the body via defecation. [3] Physicians who specialize in the medical specialty of gastroenterology are called gastroenterologists or sometimes GI doctors.
The gastrointestinal wall is inflamed in a number of conditions. This is called esophagitis , gastritis , duodenitis , ileitis , and colitis depending on the parts affected. It can be due to infections or other conditions, including coeliac disease , and inflammatory bowel disease affects the layers of the gastrointestinal tract in different ways.
Layers of the Alimentary Canal.The wall of the alimentary canal has four basic tissue layers: the mucosa, submucosa, muscularis, and serosa. The enteric nervous system in humans consists of some 500 million neurons [11] (including the various types of Dogiel cells), [1] [12] 0.5% of the number of neurons in the brain, five times as many as the one hundred million neurons in the human spinal ...
The gastrointestinal hormones (or gut hormones) constitute a group of hormones secreted by enteroendocrine cells in the stomach, pancreas, and small intestine that control various functions of the digestive organs.
Enteroendocrine cells are specialized cells of the gastrointestinal tract and pancreas with endocrine function. They produce gastrointestinal hormones or peptides in response to various stimuli and release them into the bloodstream for systemic effect, diffuse them as local messengers, or transmit them to the enteric nervous system to activate nervous responses.