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[12] [13] Social interaction is measured by how the mouse interacts with a stranger mouse introduced in the opposite side of a test box. [14] Researchers from the University of Florida have used deer mice to study restricted and repetitive behavior such as compulsive grooming, and how these behaviors may be caused by specific gene mutations. [15]
Conditioned place preference (CPP) is a form of Pavlovian conditioning used to measure the motivational effects of objects or experiences. [1] This motivation comes from the pleasurable aspect of the experience, so that the brain can be reminded of the context that surrounded the "encounter". [2]
Nrg1(ΔEGF) +/− mice have been shown to have social interaction problems, reduced prepulse of inhibition and greater spontaneous locomotion. Other neuregulin 1 models include the heterozygous removal of the transmembrane domain (Nrg1(ΔTM) +/− mice) and the immunoglobulin domain (Nrg1(ΔIg) +/− mice).
It is difficult to develop an animal model that perfectly reproduces the symptoms of depression in patients. It is generic that 3 standards may be used to evaluate the reliability of an animal version of depression: the phenomenological or morphological appearances (face validity), a comparable etiology (assemble validity), and healing similarities (predictive validity).
Calhoun himself saw the fate of the population of mice as a metaphor for the potential fate of humankind. He characterized the social breakdown as a "spiritual death", [10] with reference to bodily death as the "second death" mentioned in the Biblical verse Revelation 2:11. [10] The implications of the experiment are controversial.
The last surviving birth was on day 600, bringing the total population to a mere 2200 mice, even though the experiment setup allowed for as many as 3840 mice in terms of nesting space. This period between day 315 and day 600 saw a breakdown in social structure and in normal social behavior. Among the aberrations in behavior were the following ...
Social environment confinement produces similar effects to physical confined environments. The AARP study on social isolation by age, the Amish community, Oxana Malaya (the feral child), Amala and Kamala (the "wolf-like children") and mice/rat experiments are examples of psychological changes caused by limited social interaction.
This test involves two mice from a cage meeting head to head in a small tube. [12] Since both mice cannot fit to pass each other in the tube, one mouse is pushed by the other. The winner of this social encounter is the mouse that pushes the other mouse out. [12]