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Felty's syndrome (FS), also called Felty syndrome, [1] is a rare autoimmune disease characterized by the triad of rheumatoid arthritis, enlargement of the spleen and low neutrophil count. The condition is more common in those aged 50–70 years, specifically more prevalent in females than males, and more so in Caucasians than those of African ...
Autoimmune hepatitis, formerly known as lupoid hepatitis, plasma cell hepatitis, or autoimmune chronic active hepatitis, is a chronic, autoimmune disease of the liver that occurs when the body's immune system attacks liver cells, causing the liver to be inflamed.
This article provides a list of autoimmune diseases. These conditions, where the body's immune system mistakenly attacks its own cells, affect a range of organs and systems within the body. Each disorder is listed with the primary organ or body part that it affects and the associated autoantibodies that are typically found in people diagnosed ...
The liver is enlarged (hepatomegaly) in 30–40% of patients. [citation needed] Autoimmune disease is the second most common clinical manifestation and one that most often requires treatment. The most common autoimmune presentations include autoimmune cytopenias, which can be mild to very severe and intermittent or chronic. [5]
A key difference is a malfunction of the innate immune system in autoinflammatory diseases, whereas in autoimmune diseases there is a malfunction of the adaptive immune system. [ 8 ] Symptoms of autoimmune diseases can significantly vary, primarily based on the specific type of the disease and the body part that it affects.
The parasite migrates to the internal organs such as the liver, spleen (hence "visceral"), and bone marrow, and, if left untreated, will almost always result in the death of the host. Signs and symptoms include fever , weight loss , fatigue , anemia , and substantial swelling of the liver and spleen .
This month, the FDA granted accelerated approval to Iqirvo (elafibranor) for the treatment of an autoimmune disease that can affect the liver called primary biliary cholangitis.
In 27% to 50% of cases there is an associated malignancy or a predisposing autoimmune disease. [4] [5] [12] Pre-existing autoimmune diseases can include autoimmune lymphoproliferative syndrome (ALPS), combined variable immunodeficiency (CVID), systemic autoimmune disease, or another disorder of immune dysregulation. [13]