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A second major cause is an age-related decline in stomach acid production (achlorhydria), because acid exposure frees protein-bound vitamin. [12] For the same reason, people on long-term antacid therapy, using proton-pump inhibitors, H 2 blockers or other antacids are at increased risk. [13]
Major depressive disorder (MDD), also known as clinical depression, is a mental disorder [9] characterized by at least two weeks of pervasive low mood, low self-esteem, and loss of interest or pleasure in normally enjoyable activities. Introduced by a group of US clinicians in the mid-1970s, [10] the term was adopted by the American Psychiatric ...
Hyperhomocysteinemia. Hyperhomocysteinemia is a medical condition characterized by an abnormally high level of total homocysteine (that is, including homocystine and homocysteine-cysteine disulfide) in the blood, conventionally described as above 15 μmol/L. [1] As a consequence of the biochemical reactions in which homocysteine is involved ...
Over time, a deficiency of B12 can cause problems with balance, confusion, depression, poor memory and possibly dementia, and it can even cause permanent damage to the nervous system, Somers says.
Biology of depression. Scientific studies have found that different brain areas show altered activity in humans with major depressive disorder (MDD), [1] and this has encouraged advocates of various theories that seek to identify a biochemical origin of the disease, as opposed to theories that emphasize psychological or situational causes.
There are many psychiatric and medical conditions that may mimic some or all of the symptoms of depression or may occur comorbid to it. [11] [12] [13] A disorder either psychiatric or medical that shares symptoms and characteristics of another disorder, and may be the true cause of the presenting symptoms is known as a differential diagnosis. [14]
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