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A transcriptome-wide analysis in mice found that a protein-restricted (PR) diet during gestation resulted in differential gene expression in approximately 1% of the fetal genes analyzed (235/22,690). Specifically, increased expression was seen in genes involved in the p53 pathway, apoptosis , negative regulators of cell metabolism, and genes ...
Nutritional genomics, also known as nutrigenomics, is a science studying the relationship between human genome, human nutrition and health. People in the field work toward developing an understanding of how the whole body responds to a food via systems biology, as well as single gene/single food compound relationships.
Furthermore, nutrition can affect methylation as the process continues throughout an individual’s adult life. Because of this, nutritional epigeneticists have studied food as a form of molecular exposure. [1] DNA methylation is the addition of a methyl group on a cytosine ring of DNA. [15]
Methylation, as well as other epigenetic modifications, affects transcription, gene stability, and parental imprinting. [2] It directly impacts chromatin structure and can modulate gene transcription, or even completely silence or activate genes, without mutation to the gene itself. Though the mechanisms of this genetic control are complex ...
Differentially methylated regions (DMRs) are genomic regions with different DNA methylation status across different biological samples and regarded as possible functional regions involved in gene transcriptional regulation. The biological samples can be different cells/tissues within the same individual, the same cell/tissue at different times ...
Epigenomics is the study of the complete set of epigenetic modifications on the genetic material of a cell, known as the epigenome.The field is analogous to genomics and proteomics, which are the study of the genome and proteome of a cell.
17314 Ensembl ENSG00000170430 ENSMUSG00000054612 UniProt P16455 P26187 RefSeq (mRNA) NM_002412 NM_008598 NM_001377037 RefSeq (protein) NP_002403 NP_032624 NP_001363966 Location (UCSC) Chr 10: 129.47 – 129.77 Mb Chr 7: 136.5 – 136.73 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Methylated-DNA--protein-cysteine methyltransferase (MGMT), also known as O 6 -alkylguanine DNA ...
Vitamin B12 deficiency in mice has been shown to alter expression of histone modifying enzymes in the brain, leading to behavioral changes and epigenetic reprogramming. [41] Evidences also show the importance of HDACs in regulation of lipid metabolism and other metabolic pathways playing a role in the pathophysiology of metabolic disorders.