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Technetium (99m Tc) sestamibi is a lipophilic cation which, when injected intravenously into a patient, distributes in the myocardium proportionally to the myocardial blood flow. Single photon emission computed tomography imaging of the heart is performed using a gamma camera to detect the gamma rays emitted by the technetium-99m as it decays.
Technetium-99m (Tc-99m) can be readily detected in the body by medical equipment because it emits 140.5 keV gamma rays (these are about the same wavelength as emitted by conventional X-ray diagnostic equipment), and its half-life for gamma emission is six hours (meaning 94% of it decays to 99 Tc in 24 hours). Besides, it emits virtually no beta ...
By the late 1980s, two different compounds containing technetium-99m were introduced: teboroxime [10] and sestamibi. The utilization of Tc-99m would allow higher doses (up to 1,100 MBq or 30 mCi) due to the shorter physical (6 hours) half life of Tc-99m.
A cardiac specific radiopharmaceutical is administered, e.g., 99m Tc-tetrofosmin (Myoview, GE healthcare), 99m Tc-sestamibi (Cardiolite, Bristol-Myers Squibb) or Thallium-201 chloride. Following this, the heart rate is raised to induce myocardial stress, either by exercise on a treadmill or pharmacologically with adenosine , dobutamine , or ...
A nuclear medicine parathyroid scan demonstrates a parathyroid adenoma adjacent to the left inferior pole of the thyroid gland. The above study was performed with Technetium-Sestamibi (1st column) and Iodine-123 (2nd column) simultaneous imaging and the subtraction technique (3rd column).
Technetium (99m Tc) sestamibi ("Cardiolite") is widely used for imaging of the heart. Technetium forms a variety of coordination complexes with organic ligands. Many have been well-investigated because of their relevance to nuclear medicine. [51] Technetium forms a variety of compounds with Tc–C bonds, i.e. organotechnetium complexes.
Technetium (99mTc) albumin aggregated; Technetium (99mTc) arcitumomab; Technetium (99mTc) etarfolatide; Technetium (99mTc) exametazime; Technetium (99mTc) fanolesomab; Technetium (99mTc) mebrofenin; Technetium (99mTc) medronic acid; Technetium (99mTc) nofetumomab merpentan; Technetium (99mTc) pintumomab; Technetium (99mTc) sestamibi; Technetium ...
[[Technetium (99m Tc) sestamibi]] ("Cardiolite") is widely used for imaging of the heart. Technetium forms a variety of coordination complexes with organic ligands. Many have been well-investigated because of their relevance to nuclear medicine. [19] Technetium forms a variety of compounds with Tc–C bonds, i.e. organotechnetium complexes.