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Five modern technetium-99m generators The first technetium-99m generator, unshielded, 1958. A Tc-99m pertechnetate solution is being eluted from Mo-99 molybdate bound to a chromatographic substrate. A technetium-99m generator, or colloquially a technetium cow or moly cow, is a device used to extract the metastable isotope 99m Tc of technetium ...
At the hospital, the 99m Tc that forms through 99 Mo decay is chemically extracted from the technetium-99m generator. Most commercial 99 Mo/ 99m Tc generators use column chromatography , in which 99 Mo in the form of water-soluble molybdate, MoO 4 2− is adsorbed onto acid alumina (Al 2 O 3 ).
In particular it is used to carry the 99m Tc isotope (half-life 6 hours) which is commonly used in nuclear medicine in several nuclear scanning procedures. Pertechnetate is poorly hydrated as [TcO 4 (H 2 O) n ] − and [TcO 4 (H 2 O) n-m ] − [H 3 O] + m (n = 1–50, m = 1–4) clusters that have been demonstrated by simulation with DFT.
The metastable technetium-99m (99m Tc) is a short-lived (half-life about 6 hours) nuclear isomer used in nuclear medicine, produced from molybdenum-99. It decays by isomeric transition to technetium-99, a desirable characteristic, since the very long half-life and type of decay of technetium-99 imposes little further radiation burden on the body.
The metastable nuclear isomer technetium-99m is a gamma-ray emitter widely used for medical diagnostics because it has a short half-life of 6 hours, but can be easily made in the hospital using a technetium-99m generator.
99m Tc is a very versatile radioisotope, and is the most commonly used radioisotope tracer in medicine. It is easy to produce in a technetium-99m generator, by decay of 99 Mo. 99 Mo → 99m Tc + e − + ν e. The molybdenum isotope has a half-life of approximately 66 hours (2.75 days), so the generator has a useful life of about two weeks.
Technetium-99m: A Crucial Diagnostic Tool for Modern Medicine. Technetium-99m is one of the most widely used radiopharmaceuticals in diagnostic imaging due to its ability to provide high-quality, real-time images of internal bodily processes. Its use in various scans, such as bone, renal, cardiac, and neurological scans, makes it indispensable ...
Technetium also has numerous nuclear isomers, which are isotopes with one or more excited nucleons. Technetium-97m (97m Tc; "m" stands for metastability) is the most stable, with a half-life of 91 days and excitation energy 0.0965 MeV. [58] This is followed by technetium-95m (61 days, 0.03 MeV), and technetium-99m (6.01 hours, 0.142 MeV). [58]