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Parkinson's disease (PD), or simply Parkinson's, is a neurodegenerative disease primarily of the central nervous system, affecting both motor and non-motor systems. Symptoms typically develop gradually, with non-motor issues becoming more prevalent as the disease progresses.
Parkinson's Disease causes constipation and gastric dysmotility that is severe enough to endanger comfort and even health. [26] A factor in this is the appearance of Lewy bodies and Lewy neurites even before these affect the functioning of the substantia nigra in the neurons in the enteric nervous system that control gut functions. [27]
Parkinsonism is a clinical syndrome characterized by the four motor symptoms found in Parkinson's disease: tremor, bradykinesia (slowed movements), rigidity, and postural instability. [ 1 ] [ 2 ] Parkinsonism gait problems can lead to falls and serious physical injuries.
The history of Parkinson's disease expands from 1817, when British apothecary James Parkinson published An Essay on the Shaking Palsy, to modern times. Before Parkinson's descriptions, others had already described features of the disease that would bear his name, while the 20th century greatly improved knowledge of the disease and its ...
Parkinson's (disambiguation) Parkinson's disease, degenerative disorder of the central nervous system; Parkinsonism, also known as Parkinson's syndrome, atypical Parkinson's, or secondary Parkinson's; Parkinson's Law, the adage "Work expands so as to fill the time available for its completion."
Parkinson’s disease was correlated with genes linked to intracranial and subcortical brain volumes. ADHD, insomnia , and neuroticism were negatively correlated with genes controlling ...
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