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The target selection process of an axon to develop synaptic connections with specific cells can be broken down into multiple stages that are not necessarily confined to exact chronological order. [2] The stages of targeting include: [1] [2] region specification; target cell specification; subcellular specification; synaptic refinement
Brain cells make up the functional tissue of the brain. The rest of the brain tissue is the structural stroma that includes connective tissue such as the meninges, blood vessels, and ducts. The two main types of cells in the brain are neurons, also known as nerve cells, and glial cells, also known as neuroglia. [1]
The human brain is the central organ of the nervous system, and with the spinal cord, comprises the central nervous system. It consists of the cerebrum, the brainstem and the cerebellum. The brain controls most of the activities of the body, processing, integrating, and coordinating the information it receives from the sensory nervous system ...
The essential function of the brain is cell-to-cell communication, and synapses are the points at which communication occurs. The human brain has been estimated to contain approximately 100 trillion synapses; [12] even the brain of a fruit fly contains several million. [13]
A neuron, neurone, [1] or nerve cell is an excitable cell that fires electric signals called action potentials across a neural network in the nervous system.They are located in the brain and spinal cord and help to receive and conduct impulses.
Basket cells are multipolar GABAergic interneurons that function to make inhibitory synapses and control the overall potentials of target cells. In general, dendrites of basket cells are free branching, contain smooth spines, and extend from 3 to 9 mm. Axons are highly branched, ranging in total from 20 to 50mm in total length.
The striatum (pl.: striata) or corpus striatum [5] is a cluster of interconnected nuclei that make up the largest structure of the subcortical basal ganglia. [6] The striatum is a critical component of the motor and reward systems; receives glutamatergic and dopaminergic inputs from different sources; and serves as the primary input to the rest of the basal ganglia.
Satellite glial cells are a type of glia found in the peripheral nervous system, specifically in sensory, [2] sympathetic, and parasympathetic ganglia. [3] They compose the thin cellular sheaths that surround the individual neurons in these ganglia. In a SGC, the cell body is denoted by the region containing the single, relatively large nucleus ...