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In molecular biology, SWI/SNF (SWItch/Sucrose Non-Fermentable), [1] [2] is a subfamily of ATP-dependent chromatin remodeling complexes, which is found in eukaryotes. In other words, it is a group of proteins that associate to remodel the way DNA is packaged.
There are four subfamilies of chromatin remodelers: SWI/SNF, INO80, ISW1, and CHD. [2] The RSC complex is a 15-subunit chromatin remodeling complex initially found in Saccharomyces cerevisiae, and is homologous to the SWI/SNF complex found in humans. [1] The RSC complex has ATPase activity in the presence of DNA. [1]
Susceptibility weighted imaging (SWI), originally called BOLD venographic imaging, is an MRI sequence that is exquisitely sensitive to venous blood, hemorrhage and iron storage. SWI uses a fully flow compensated, long echo, gradient recalled echo (GRE) pulse sequence to acquire images.
Since the original observation of SMARCB1 mutations in rhabdoid tumors, several more subunits of the human SWI/SNF chromatin remodeling complex have been found mutated in a wide range of neoplasms. [26] The SWI/SNF ATPase BRG1 (or SMARCA4) is the most frequently mutated chromatin remodeling ATPase in cancer. [27]
Since the TATA sequence is inside a nucleosome, adding ATP will cause human SWI/SNF to recognize its chromatin structure and alter the nucleosomal DNA sequence so that the TPB can access and bind to it. [10] From a broader perspective, this allows for more eukaryotic gene expression, since a variety of eukaryotic promoters will be regulated. [10]
The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes.
57376 Ensembl ENSG00000073584 ENSMUSG00000037935 UniProt Q969G3 O54941 RefSeq (mRNA) NM_003079 NM_020618 RefSeq (protein) NP_003070 NP_003070.3 NP_065643 Location (UCSC) Chr 17: 40.62 – 40.65 Mb Chr 11: 99.1 – 99.12 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 is a protein that in ...
Gene encoding for ARID1A is the most frequently mutated SWI/SNF subunit across cancers. [9] This gene has been commonly found mutated in different cancers leading to loss of function, including gastric cancers, [10] colon cancer, [11] ovarian clear cell carcinoma, [12] liver cancer, [13] lymphoma [14] and pancreatic cancer. [15]