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Lipid metabolism is often considered the digestion and absorption process of dietary fat; however, there are two sources of fats that organisms can use to obtain energy: from consumed dietary fats and from stored fat. [5] Vertebrates (including humans) use both sources of fat to produce energy for organs such as the heart to function. [6]
White adipose tissue, also known as white fat, is one two types of adipose tissue in mammals. White adipose tissue stores energy in the form of triglycerides, which can be broken down to free fatty acids on demand. Its normal function is to store free fatty acids as triglycerides within the tissue.
In sheep kidney tissue, very high rates of gluconeogenesis from propionate have been observed. [ 26 ] In all species, the formation of oxaloacetate from pyruvate and TCA cycle intermediates is restricted to the mitochondrion, and the enzymes that convert Phosphoenolpyruvic acid (PEP) to glucose-6-phosphate are found in the cytosol. [ 27 ]
A young adult human's fat stores average between about 15–20 kg (33–44 lb), but varies greatly depending on age, sex, and individual disposition. [10] In contrast, the human body stores only about 400 g (0.9 lb) of glycogen , of which 300 g (0.7 lb) is locked inside the skeletal muscles and is unavailable to the body as a whole.
Ectopic fat is the storage of triglycerides in tissues other than adipose tissue, that are supposed to contain only small amounts of fat, such as the liver, skeletal muscle, heart, and pancreas. [1] This can interfere with cellular functions and hence organ function and is associated with insulin resistance in type-2 diabetes. [ 46 ]
Lipid droplets, also referred to as lipid bodies, oil bodies or adiposomes, [1] are lipid-rich cellular organelles that regulate the storage and hydrolysis of neutral lipids and are found largely in the adipose tissue. [2] They also serve as a reservoir for cholesterol and acyl-glycerols for membrane formation and maintenance.
A genetic disorder causing multiple cysts to form in the liver tissue, usually in later life, and usually asymptomatic, is polycystic liver disease. Diseases that interfere with liver function will lead to derangement of these processes. However, the liver has a great capacity to regenerate and has a large reserve capacity. In most cases, the ...
A typical fat cell is 0.1 mm in diameter [2] with some being twice that size, and others half that size. However, these numerical estimates of fat cell size depend largely on the measurement method and the location of the adipose tissue. [2] The fat stored is in a semi-liquid state, and is composed primarily of triglycerides, and cholesteryl ester.