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The Common Terminology Criteria for Adverse Events (CTCAE), [1] formerly called the Common Toxicity Criteria (CTC or NCI-CTC), are a set of criteria for the standardized classification of adverse events of drugs and treatment used in cancer therapy. The CTCAE system is a product of the US National Cancer Institute (NCI).
1957: The first cancer, choriocarcinoma, was cured with chemotherapy at NCI. 1960: NCI began funding government-supported cancer centers. 1971: President Richard Nixon converted the U.S. Army's former biological warfare facilities at Fort Detrick, Maryland, to house research activities on the causes, treatment, and prevention of cancer.
Cancer is a significant issue that is affecting the world. Specifically in the U.S., 1,735,350 new cases of cancer, and 609,640 deaths were expected by the end of 2018. Adequate treatment can prevent many cancer deaths but there are racial and social disparities in treatments which has a significant factor in high death rates.
The Consensus Development Program is an initiative focused on gathering expert opinions to establish standards and guidelines in various fields, especially in health and medicine. Developed as a collaborative effort by organizations such as the NIH, the program assembles panels of specialists who assess available evidence on critical topics and ...
Cancer centers must renew their status with the NIH every 5 years. The NIH funds cancer centers through a P30 Cancer Center Support Grant (CCSG) mechanism. [2] To be eligible to apply, a cancer center must receive at least $10 million in cancer research funding annually. Preparation for these grant applications can be extensive.
Patients and their diseases are profiled in order to identify the most effective treatment for their specific case. Targeted therapy or molecularly targeted therapy is one of the major modalities of medical treatment (pharmacotherapy) for cancer, [1] others being hormonal therapy and cytotoxic chemotherapy.
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