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Molecular Biology of the Cell (4th ed.). New York: Garland Science. ISBN 978-0-8153-3218-3. Intercellular+Junctions at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Cell-Matrix+Junctions at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Biochemical analysis of gap junction isolated from various tissues demonstrated a family of connexins. [140] [141] [142] The ultrastructure and biochemistry of isolated gap junctions already referenced had indicated the connexins preferentially group in gap junction plaques or domains and connexins were the best characterized constituent.
RuvA (Holliday junction branch migration complex subunit RuvA) [4] is a DNA-binding protein that binds Holliday junctions with high affinity. The structure of the complex has been variously elucidated through X-ray crystallography and EM data, and suggest that the complex consists of either one or two RuvA tetramers, with charge lined grooves through which the incoming DNA is channelled.
Schematic of cell adhesion. Cell adhesion is the process by which cells interact and attach to neighbouring cells through specialised molecules of the cell surface. This process can occur either through direct contact between cell surfaces such as cell junctions or indirect interaction, where cells attach to surrounding extracellular matrix, a gel-like structure containing molecules released ...
As ATP is hydrolyzed, RuvB rotates the recombined strands while pulling them out of the junction, but does not separate the strands as helicase would. [3] The final step in branch migration is called resolution and requires the protein RuvC. The protein is a dimer, and will bind to the Holliday junction when it takes on the stacked X form.
The role of JAM-1 in tight junction biology is to function through mediation partly due to the localization of the Par-αPKC complex at adherens junctions during junction creation. [3] Once the tight junction is formed, many JAM-1 proteins are present, many of which are now phosphorylated at Ser285. [3]
The structure that results is a cross-strand exchange, also known as a Holliday junction. The contact between two chromatids that will soon undergo crossing-over is known as a chiasma. The Holliday junction is a tetrahedral structure which can be 'pulled' by other recombinases, moving it along the four-stranded structure. [citation needed]
The two pathways for homologous recombination in eukaryotes, showing the formation and resolution of Holliday junctions. The Holliday junction is a key intermediate in homologous recombination, a biological process that increases genetic diversity by shifting genes between two chromosomes, as well as site-specific recombination events involving integrases.