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Extrapyramidal symptoms including dyskinesias (acute & delayed) Dystonic reactions; Cogwheel rigidity; Emotional lability; Psychosis; Suicidal ideation; Ataxias; Transient difficulty with recall; Serotonin syndrome; Parkinsonism; Restless leg syndrome; Restlessness; Eye pain; Altered sense of smell; Photophobia; Pressure on eyes; Inner ear ...
Common side effects of buspirone include nausea, headaches, dizziness, and difficulty concentrating. [10] [12] Serious side effects may include movement disorders, serotonin syndrome, and seizures. [12] Its use in pregnancy appears to be safe but has not been well studied, and use during breastfeeding has not been well studied either. [12] [13]
Buspar – an anxiolytic used to treat generalized anxiety disorder; Belbuca, Buprenex, Butrans, Subutex, Probuohine (buprenorphine) - an opioid medicine used to treat moderate to severe pain, and in some formulations to treat opioid use disorder; Belsomra – used to treat insomnia
A common metabolite of several azapirones including buspirone, gepirone, ipsapirone, revospirone, and tandospirone is 1-(2-pyrimidinyl)piperazine (1-PP). [47] [48] [49] 1-PP possesses 5-HT 1A partial agonist and α 2-adrenergic antagonist actions and likely contributes overall mostly to side effects. [47] [48] [50]
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Medications are used to reverse the symptoms of extrapyramidal side effects caused by antipsychotics or other drugs, by either directly or indirectly increasing dopaminergic neurotransmission. The treatment varies by the type of the EPS, but may involve anticholinergic agents such as procyclidine , benztropine , diphenhydramine , and ...