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Chondroitin sulfate is an important structural component of cartilage, [2] and provides much of its resistance to compression. [3] Along with glucosamine, chondroitin sulfate has become a widely used dietary supplement for treatment of osteoarthritis, although large clinical trials failed to demonstrate any symptomatic benefit of chondroitin.
A chondroitin is a chondrin derivative. [1] Types include: Chondroitin sulfate. Dermatan sulfate. Chondroitin as a supplement is now commonly used (often in combination with glucosamine) in treating the joint disease of osteoarthritis. [2] In contrast to the symptomatic treatments, chondroitin can modify the progression of a disease process in ...
Chondroitin sulfate proteoglycan. Chondroitin sulfate proteoglycans (CSPGs) are proteoglycans consisting of a protein core and a chondroitin sulfate side chain. They are known to be structural components of a variety of human tissues, including cartilage, and also play key roles in neural development and glial scar formation.
Use of chondroitin in routine clinical practice should therefore be discouraged." Also in 2007, Bruyere et al. [45] without using explicit methodology for reviewing trials concluded "there is compelling evidence that glucosamine sulfate and chondroitin sulfate may interfere with progression of OA." The effectiveness of glucosamine is controversial.
Glycosaminoglycan. The repeating disaccharide unit (GlcUA (1β→3)GalNAc (1β→4)) n of chondroitin sulfate. For polysaccharide nomenclature see here. R 1, R 2, R 3 may have different values. Glycosaminoglycans[1] (GAGs) or mucopolysaccharides[2] are long, linear polysaccharides consisting of repeating disaccharide units (i.e. two-sugar units).
When chondroitin sulfate proteoglycans are bonded to their side chains called chondroitin sulfate glycosaminoglycans, these molecules are known to prevent neural restoration to the damaged region of the central nervous system because they form glial scar tissue which inhibits both neuroplasticity and repair of damaged axons.