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Osteoarthritis (OA) is a type of degenerative joint disease that results from breakdown of joint cartilage and underlying bone. [5][6] It is believed to be the fourth leading cause of disability in the world, affecting 1 in 7 adults in the United States alone. [7] The most common symptoms are joint pain and stiffness. [1]
Gene therapy for osteoarthritis. Gene therapy for osteoarthritis is the application of gene therapy to treat osteoarthritis (OA). Unlike pharmacological treatments which are administered locally or systemically as a series of interventions, gene therapy aims to establish sustained therapeutic effect after a single, local injection. [1]
Arthritis is a term often used to mean any disorder that affects joints. [2] Symptoms generally include joint pain and stiffness. [2] Other symptoms may include redness, warmth, swelling, and decreased range of motion of the affected joints. [2][3] In some types of arthritis, other organs are also affected. [7]
Post-traumatic arthritis is a form of osteoarthritis and the former can occur after the latter. However, post-traumatic arthritis can also occur after the development of chronic inflammatory arthritis. Generally, post-traumatic arthritis is classified in two groups: post-traumatic osteoarthritis and post-traumatic inflammatory arthritis.
A disease-modifying osteoarthritis drug (DMOAD) is a disease-modifying drug that would inhibit or even reverse the progression of osteoarthritis. [1] Since the main hallmark of osteoarthritis is cartilage loss, a typical DMOAD would prevent the loss of cartilage and potentially regenerate it. Other DMOADs may attempt to help repair adjacent ...
In medicine, a joint injection (intra-articular injection) is a procedure used in the treatment of inflammatory joint conditions, such as rheumatoid arthritis, psoriatic arthritis, gout, tendinitis, bursitis, Carpal Tunnel Syndrome, [2] and occasionally osteoarthritis. [3][4] A hypodermic needle is injected into the affected joint where it ...
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