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The LD 50 of MSM is greater than 17.5 grams per kilogram of body weight. In rats, no adverse events were observed after daily doses of 2 g MSM per kg of body weight. In a 90-day follow-up study, rats received daily MSM doses of 1.5 g/kg, and no changes were observed in terms of symptoms, blood chemistry or gross pathology. [23]
Urinary tract infection in pediatric patients is a significant clinical issue, affecting approximately 7% of fevered infants and children. [43] If left untreated, the infection can ascend from the bladder to the kidneys, resulting in acute pyelonephritis, which leads to hypertension , kidney scarring , and end-stage kidney disease .
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A urinary tract infection (UTI) is an infection that affects a part of the urinary tract. [1] Lower urinary tract infections may involve the bladder (cystitis) or urethra (urethritis) while upper urinary tract infections affect the kidney (pyelonephritis). [10] Symptoms from a lower urinary tract infection include suprapubic pain, painful ...
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Uromune, also known by its developmental code name MV-140, is a polyvalent bacterial vaccine which is used in the prevention of recurrent urinary tract infections (UTIs). [1] [2] [3] In clinical studies, it has been found to reduce total number of UTIs (by ~70%), to increase UTI-free rates (from 25% to ~57%), and to increase time to next UTI (from 48 days to 275 days), as well as to reduce UTI ...