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Herpetic simplex keratitis is a form of keratitis caused by recurrent herpes simplex virus (HSV) infection in the cornea. [ 1 ] It begins with infection of epithelial cells on the surface of the eye and retrograde infection of nerves serving the cornea. [ 2 ]
About 3 to 6 million people get acute conjunctivitis each year in the United States. [1] [3] Typically, people get better in one or two weeks. [1] [3] If visual loss, significant pain, sensitivity to light or signs of herpes occur, or if symptoms do not improve after a week, further diagnosis and treatment may be required. [3]
Aciclovir acts by inhibiting viral DNA replication and is used for the treatment of herpes simplex virus (HSV) and varicella zoster virus infections, including: [3] [15] [16] Genital herpes simplex (treatment and prevention) Neonatal herpes simplex; Herpes simplex labialis ; Shingles; Acute chickenpox in immunocompromised patients
The herpes zoster vaccine is recommended for prevention in those over the age of 50. [2] HZO is the second most common manifestation of shingles, the first being involvement of skin of the thorax. [citation needed] Shingles affects up to one half million people in the United States per year, of which 10% to 25% is HZO. [1] [3]
The majority of people with poor vision are in the developing world and are over the age of 50 years. [1] Rates of visual impairment have decreased since the 1990s. [1] Visual impairments have considerable economic costs both directly due to the cost of treatment and indirectly due to decreased ability to work. [16]
Another analysis has estimated the mutation rate in the herpes simplex 1 genome to be 1.82×10 −8 nucleotide substitution per site per year. This analysis placed the most recent common ancestor of this virus ~710,000 years ago. [62] Herpes simplex 1 and 2 diverged about 60]
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