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Analgesic and behavioral effects were reported for 12 hours and plasma samples were analyzed for oxycodone metabolites for 48 hours. Grapefruit juice increased the mean area under the oxycodone concentration-time curve (AUC(0-∞)) by 1.7 fold, the peak plasma concentration by 1.5-fold and the half-life of oxycodone by 1.2-fold as compared to ...
The symptoms seen with the interaction vary from medication to medication — the symptoms are not from the grapefruit. They're from the medication." ... "Many food-drug interactions and potential ...
Statins to lower cholesterol, such as Lipitor (atorvastatin) and Zocor (simvastatin) ... “This may increase GERD symptoms.” The Bottom Line. Grapefruit is a nutrition powerhouse filled with ...
Important: If you're taking statins or medications for conditions like high blood pressure, cholesterol, heart arrhythmia, organ transplants, or allergies, it can be dangerous to eat grapefruit ...
People taking atorvastatin should consult with their doctor or pharmacist before consuming grapefruit juice, as the effects of grapefruit juice consumption on atorvastatin will vary according to factors such as the amount and frequency of juice consumption in addition to differences in juice components, quality and method of juice preparation ...
As with atorvastatin, simvastatin, and other statin drugs metabolized via CYP3A4, drinking grapefruit juice during lovastatin therapy may increase the risk of side effects. Components of grapefruit juice, the flavonoid naringin, or the furanocoumarin bergamottin inhibit CYP3A4 in vitro, [13] and may account for the in vivo effect of grapefruit ...
Grapefruit and grapefruit juice have been found to interact with numerous drugs, in many cases resulting in adverse effects. [4] This happens in two ways: one is that grapefruit can block an enzyme which metabolizes medication, [5] and if the drug is not metabolized, then the level of the drug in the blood can become too high, leading to an adverse effect. [5]
According to Harvard Health Publishing, grapefruit can be dangerous when combined with drugs used for high blood pressure, high cholesterol, and depression. Check with your doctor for guidance on ...