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Postherpetic neuralgia (PHN) is neuropathic pain that occurs due to damage to a peripheral nerve caused by the reactivation of the varicella zoster virus (herpes zoster, also known as shingles). PHN is defined as pain in a dermatomal distribution that lasts for at least 90 days after an outbreak of herpes zoster. [ 1 ]
The blisters fill with pus, break open (3), crust over (4), and finally disappear. This process takes four to five weeks. A painful condition called post-herpetic neuralgia can sometimes occur. This condition is thought to be caused by damage to the nerves (5), and can last from weeks to years after the rash disappears.
In some people, shingles can reactivate presenting as zoster sine herpete: pain radiating along the path of a single spinal nerve (a dermatomal distribution), but without an accompanying rash. This condition may involve complications that affect several levels of the nervous system and cause many cranial neuropathies , polyneuritis , myelitis ...
A dermatome is an area of skin that is mainly supplied by afferent nerve fibres from the dorsal root of any given spinal nerve. [1] [2] There are 8 cervical nerves (C1 being an exception with no dermatome), 12 thoracic nerves, 5 lumbar nerves and 5 sacral nerves.
An action potential (or nerve impulse) is a transient alteration of the transmembrane voltage (or membrane potential) across the membrane in an excitable cell generated by the activity of voltage-gated ion channels embedded in the membrane. The best known action potentials are pulse-like waves that travel along the axons of neurons.
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A neural pathway connects one part of the nervous system to another using bundles of axons called tracts. The optic tract that extends from the optic nerve is an example of a neural pathway because it connects the eye to the brain; additional pathways within the brain connect to the visual cortex.
Projection fibers consist of efferent and afferent fibers uniting the cortex with the lower parts of the brain and with the spinal cord.In human neuroanatomy, bundles of axons (nerve fibers) called nerve tracts, within the brain, can be categorized by their function into association tracts, projection tracts, and commissural tracts.
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